Divergent synthetic approach to 6”-modified α-GalCer analogues

A synthetic approach is presented for the synthesis of galacturonic acid and d-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6”-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6”-modified KRN7000 analogues.

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Detalles Bibliográficos
Autores principales: Pauwels, Nora, Aspeslagh, Sandrine, Vanhoenacker, Gerd, Sandra, Koen, Yu, Esther D., Zajonc, Dirk M., Elewaut, Dirk, Linclau, Bruno, Van Calenbergh, Serge
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246390/
https://ncbi.nlm.nih.gov/pubmed/22042483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1ob06235b
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