Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism

Many tumor cells rely on aerobic glycolysis instead of oxidative phosphorylation for their continued proliferation and survival. Myc and HIF-1 are believed to promote such a metabolic switch by, in part, upregulating gene expression of pyruvate dehydrogenase (PDH) kinase 1 (PDHK1), which phosphoryla...

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Autors principals: Hitosugi, Taro, Fan, Jun, Chung, Tae-Wook, Lythgoe, Katherine, Wang, Xu, Xie, Jianxin, Ge, Qingyuan, Gu, Ting-Lei, Polakiewicz, Roberto D., Roesel, Johannes L., Chen, Zhuo (Georgia), Boggon, Titus J., Lonial, Sagar, Fu, Haian, Khuri, Fadlo R., Kang, Sumin, Chen, Jing
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246218/
https://ncbi.nlm.nih.gov/pubmed/22195962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.10.015
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