Direct-coupling analysis of residue coevolution captures native contacts across many protein families

The similarity in the three-dimensional structures of homologous proteins imposes strong constraints on their sequence variability. It has long been suggested that the resulting correlations among amino acid compositions at different sequence positions can be exploited to infer spatial contacts with...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Morcos, Faruck, Pagnani, Andrea, Lunt, Bryan, Bertolino, Arianna, Marks, Debora S., Sander, Chris, Zecchina, Riccardo, Onuchic, José N., Hwa, Terence, Weigt, Martin
التنسيق: Artigo
اللغة:Inglês
منشور في: National Academy of Sciences 2011
الموضوعات:
PNAS Plus
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241805/
https://ncbi.nlm.nih.gov/pubmed/22106262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111471108
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