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Toward rationally redesigning bacterial two-component signaling systems using coevolutionary information

A challenge in molecular biology is to distinguish the key subset of residues that allow two-component signaling (TCS) proteins to recognize their correct signaling partner such that they can transiently bind and transfer signal, i.e., phosphoryl group. Detailed knowledge of this information would a...

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Autors principals: Cheng, Ryan R., Morcos, Faruck, Levine, Herbert, Onuchic, José N.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918776/
https://ncbi.nlm.nih.gov/pubmed/24449878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323734111
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