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Elucidating the druggable interface of protein−protein interactions using fragment docking and coevolutionary analysis
Protein−protein interactions play a central role in cellular function. Improving the understanding of complex formation has many practical applications, including the rational design of new therapeutic agents and the mechanisms governing signal transduction networks. The generally large, flat, and r...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5167203/ https://ncbi.nlm.nih.gov/pubmed/27911825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615932113 |
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