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Coevolutionary information, protein folding landscapes, and the thermodynamics of natural selection

The energy landscape used by nature over evolutionary timescales to select protein sequences is essentially the same as the one that folds these sequences into functioning proteins, sometimes in microseconds. We show that genomic data, physical coarse-grained free energy functions, and family-specif...

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Bibliografiska uppgifter
Huvudupphovsmän: Morcos, Faruck, Schafer, Nicholas P., Cheng, Ryan R., Onuchic, José N., Wolynes, Peter G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2014
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151759/
https://ncbi.nlm.nih.gov/pubmed/25114242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413575111
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