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Coevolutionary information, protein folding landscapes, and the thermodynamics of natural selection
The energy landscape used by nature over evolutionary timescales to select protein sequences is essentially the same as the one that folds these sequences into functioning proteins, sometimes in microseconds. We show that genomic data, physical coarse-grained free energy functions, and family-specif...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4151759/ https://ncbi.nlm.nih.gov/pubmed/25114242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413575111 |
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