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Coevolutionary information, protein folding landscapes, and the thermodynamics of natural selection

The energy landscape used by nature over evolutionary timescales to select protein sequences is essentially the same as the one that folds these sequences into functioning proteins, sometimes in microseconds. We show that genomic data, physical coarse-grained free energy functions, and family-specif...

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書誌詳細
主要な著者: Morcos, Faruck, Schafer, Nicholas P., Cheng, Ryan R., Onuchic, José N., Wolynes, Peter G.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2014
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151759/
https://ncbi.nlm.nih.gov/pubmed/25114242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413575111
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