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Coevolutionary information, protein folding landscapes, and the thermodynamics of natural selection
The energy landscape used by nature over evolutionary timescales to select protein sequences is essentially the same as the one that folds these sequences into functioning proteins, sometimes in microseconds. We show that genomic data, physical coarse-grained free energy functions, and family-specif...
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| 主要な著者: | , , , , |
|---|---|
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4151759/ https://ncbi.nlm.nih.gov/pubmed/25114242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413575111 |
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