Llwytho...

Coevolutionary information, protein folding landscapes, and the thermodynamics of natural selection

The energy landscape used by nature over evolutionary timescales to select protein sequences is essentially the same as the one that folds these sequences into functioning proteins, sometimes in microseconds. We show that genomic data, physical coarse-grained free energy functions, and family-specif...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Morcos, Faruck, Schafer, Nicholas P., Cheng, Ryan R., Onuchic, José N., Wolynes, Peter G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151759/
https://ncbi.nlm.nih.gov/pubmed/25114242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413575111
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