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Coevolutionary information, protein folding landscapes, and the thermodynamics of natural selection

The energy landscape used by nature over evolutionary timescales to select protein sequences is essentially the same as the one that folds these sequences into functioning proteins, sometimes in microseconds. We show that genomic data, physical coarse-grained free energy functions, and family-specif...

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Detaylı Bibliyografya
Asıl Yazarlar: Morcos, Faruck, Schafer, Nicholas P., Cheng, Ryan R., Onuchic, José N., Wolynes, Peter G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151759/
https://ncbi.nlm.nih.gov/pubmed/25114242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413575111
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