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Coevolutionary signals across protein lineages help capture multiple protein conformations

A long-standing problem in molecular biology is the determination of a complete functional conformational landscape of proteins. This includes not only proteins’ native structures, but also all their respective functional states, including functionally important intermediates. Here, we reveal a sign...

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Detalhes bibliográficos
Main Authors: Morcos, Faruck, Jana, Biman, Hwa, Terence, Onuchic, José N.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870752/
https://ncbi.nlm.nih.gov/pubmed/24297889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315625110
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