Direct-coupling analysis of residue coevolution captures native contacts across many protein families

The similarity in the three-dimensional structures of homologous proteins imposes strong constraints on their sequence variability. It has long been suggested that the resulting correlations among amino acid compositions at different sequence positions can be exploited to infer spatial contacts with...

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Main Authors: Morcos, Faruck, Pagnani, Andrea, Lunt, Bryan, Bertolino, Arianna, Marks, Debora S., Sander, Chris, Zecchina, Riccardo, Onuchic, José N., Hwa, Terence, Weigt, Martin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241805/
https://ncbi.nlm.nih.gov/pubmed/22106262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111471108
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