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Direct-coupling analysis of residue coevolution captures native contacts across many protein families
The similarity in the three-dimensional structures of homologous proteins imposes strong constraints on their sequence variability. It has long been suggested that the resulting correlations among amino acid compositions at different sequence positions can be exploited to infer spatial contacts with...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3241805/ https://ncbi.nlm.nih.gov/pubmed/22106262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111471108 |
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