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Genomics-aided structure prediction

We introduce a theoretical framework that exploits the ever-increasing genomic sequence information for protein structure prediction. Structure-based models are modified to incorporate constraints by a large number of non-local contacts estimated from direct coupling analysis (DCA) of co-evolving ge...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sułkowska, Joanna I., Morcos, Faruck, Weigt, Martin, Hwa, Terence, Onuchic, José N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387073/
https://ncbi.nlm.nih.gov/pubmed/22691493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207864109
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