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Topography of funneled landscapes determines the thermodynamics and kinetics of protein folding

The energy landscape approach has played a fundamental role in advancing our understanding of protein folding. Here, we quantify protein folding energy landscapes by exploring the underlying density of states. We identify three quantities essential for characterizing landscape topography: the stabil...

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Hlavní autoři: Wang, Jin, Oliveira, Ronaldo J., Chu, Xiakun, Whitford, Paul C., Chahine, Jorge, Han, Wei, Wang, Erkang, Onuchic, José N., Leite, Vitor B.P.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465441/
https://ncbi.nlm.nih.gov/pubmed/23019359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212842109
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