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Folding funnels and frustration in off-lattice minimalist protein landscapes

A full quantitative understanding of the protein folding problem is now becoming possible with the help of the energy landscape theory and the protein folding funnel concept. Good folding sequences have a landscape that resembles a rough funnel where the energy bias towards the native state is large...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Nymeyer, Hugh, García, Angel E., Onuchic, José Nelson
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1998
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC34496/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9600893/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.11.5921
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