Topography of funneled landscapes determines the thermodynamics and kinetics of protein folding

The energy landscape approach has played a fundamental role in advancing our understanding of protein folding. Here, we quantify protein folding energy landscapes by exploring the underlying density of states. We identify three quantities essential for characterizing landscape topography: the stabil...

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Bibliografske podrobnosti
Main Authors: Wang, Jin, Oliveira, Ronaldo J., Chu, Xiakun, Whitford, Paul C., Chahine, Jorge, Han, Wei, Wang, Erkang, Onuchic, José N., Leite, Vitor B.P.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465441/
https://ncbi.nlm.nih.gov/pubmed/23019359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212842109
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