Designing bacterial signaling interactions with coevolutionary landscapes

Selecting amino acids to design novel protein-protein interactions that facilitate catalysis is a daunting challenge. We propose that a computational coevolutionary landscape based on sequence analysis alone offers a major advantage over expensive, time-consuming brute-force approaches currently emp...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Cheng, Ryan R., Haglund, Ellinor, Tiee, Nicholas S., Morcos, Faruck, Levine, Herbert, Adams, Joseph A., Jennings, Patricia A., Onuchic, José N.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6101370/
https://ncbi.nlm.nih.gov/pubmed/30125296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201734
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