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Connecting the Sequence-Space of Bacterial Signaling Proteins to Phenotypes Using Coevolutionary Landscapes

Two-component signaling (TCS) is the primary means by which bacteria sense and respond to the environment. TCS involves two partner proteins working in tandem, which interact to perform cellular functions whereas limiting interactions with non-partners (i.e., cross-talk). We construct a Potts model...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Main Authors: Cheng, R. R., Nordesjö, O., Hayes, R. L., Levine, H., Flores, S. C., Onuchic, J. N., Morcos, F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100047/
https://ncbi.nlm.nih.gov/pubmed/27604223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msw188
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