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Analysis of the Functional Contributions of Asn233 in Metallo-β-Lactamase IMP-1

Metallo-β-lactamases, such as IMP-1, are a major global health threat, as they provide for bacterial resistance to a wide range of β-lactam antibiotics, including carbapenems. Understanding the molecular details of the enzymatic process and the sequence requirements for function are essential aids i...

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Autors principals: Brown, Nicholas G., Horton, Lori B., Huang, Wanzhi, Vongpunsawad, Sompong, Palzkill, Timothy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232802/
https://ncbi.nlm.nih.gov/pubmed/21896903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00340-11
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