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Structural and Mutagenic Analysis of Metallo-β-Lactamase IMP-18
IMP-type metallo-β-lactamases (MBLs) are exogenous zinc metalloenzymes that hydrolyze a broad range of β-lactams, including carbapenems. Here we report the crystal structure of IMP-18, an MBL cloned from Pseudomonas aeruginosa, at 2.0-Å resolution. The overall structure of IMP-18 resembles that of I...
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| Yayımlandı: | Antimicrob Agents Chemother |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Microbiology
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4997881/ https://ncbi.nlm.nih.gov/pubmed/27381398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00985-16 |
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