N-Arylsulfonyl Hydrazones as Inhibitors of IMP-1 Metallo-β-Lactamase

Members of a family of N-arylsulfonyl hydrazones have been identified as novel inhibitors of IMP-1, a metallo-β-lactamase of increasing prevalence. Structure-activity relationship studies have indicated a requirement for bulky aromatic substituents on each side of the sulfonyl hydrazone backbone for...

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Autores principales: Siemann, Stefan, Evanoff, Darryl P., Marrone, Laura, Clarke, Anthony J., Viswanatha, Thammaiah, Dmitrienko, Gary I.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC127367/
https://ncbi.nlm.nih.gov/pubmed/12121917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.8.2450-2457.2002
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