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Mechanistic Insights into the Activation of Oncogenic Forms of EGF Receptor
Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly activated by mutation in non-small cell lung cancer. The mechanism of this oncogenic activation is incompletely understood but, in contrast to the WT EGFR, is proposed to be independent of kinase domain dimerizati...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3230693/ https://ncbi.nlm.nih.gov/pubmed/22101934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2168 |
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