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Mechanistic insights into differential requirement of receptor dimerization for oncogenic activation of mutant EGFR and its clinical perspective

The epidermal growth factor receptor (EGFR), a member of the ErbB family (EGFR, ErbB2, ErbB3 and ErbB4), plays a crucial role in regulating various cellular responses such as proliferation, differentiation, and survival. As a result, aberrant activation of EGFR, mostly mediated through different cla...

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Bibliografske podrobnosti
izdano v:BMB Rep
Glavni avtor: Cho, Jeonghee
Format: Artigo
Jezik:Inglês
Izdano: Korean Society for Biochemistry and Molecular Biology 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7118354/
https://ncbi.nlm.nih.gov/pubmed/32172728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2020.53.3.025
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