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Autophosphorylation of the carboxyl‐terminal domain is not required for oncogenic transformation by lung‐cancer derived EGFR mutants

Aberrant activation of cancer‐derived mutants of the epidermal growth factor receptor (EGFR) is closely associated with cancer pathogenesis and is thought to be mediated through multiple tyrosine phosphorylations within the C‐terminal domain. Here, we examined the consequences of the loss of these C...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Cho, Jeonghee, Kim, Sujin, Du, Jinyan, Meyerson, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033109/
https://ncbi.nlm.nih.gov/pubmed/29464683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.31332
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