Glioblastoma-derived Epidermal Growth Factor Receptor (EGFR) carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies

Genomic alterations of the epidermal growth factor receptor (EGFR) gene play a crucial role in pathogenesis of glioblastoma multiforme (GBM). By systematic analysis of GBM genomic data, we have identified and characterized a novel exon 27 deletion mutation occurring within the EGFR carboxyl-terminus...

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Detalhes bibliográficos
Main Authors: Cho, Jeonghee, Pastorino, Sandra, Zeng, Qing, Xu, Xiaoyin, Johnson, William, Vandenberg, Scott, Verhaak, Roel, Cherniack, Andrew, Watanabe, Hideo, Dutt, Amit, Kwon, Jihyun, Chao, Ying S., Onofrio, Robert C., Chiang, Derek, Yuza, Yuki, Kesari, Santosh, Meyerson, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242822/
https://ncbi.nlm.nih.gov/pubmed/22001862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0821
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