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Epidermal growth factor receptor (EGFR) and EGFRvIII in glioblastoma (GBM): signaling pathways and targeted therapies
Amplification of EGFR and its active mutant EGFRvIII occur frequently in GBM. While EGFR and EGFRvIII play critical roles in pathogenesis, targeted therapy with EGFR-tyrosine kinase inhibitors (TKIs) or antibodies has only shown limited efficacy in patients. Here, we discuss signaling pathways media...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Oncogene |
|---|---|
| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5860944/ https://ncbi.nlm.nih.gov/pubmed/29321659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-017-0045-7 |
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