Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants

BACKGROUND: Somatic mutations in the kinase domain of the epidermal growth factor receptor tyrosine kinase gene EGFR are common in lung adenocarcinoma. The presence of mutations correlates with tumor sensitivity to the EGFR inhibitors erlotinib and gefitinib, but the transforming potential of specif...

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Hlavní autoři: Greulich, Heidi, Chen, Tzu-Hsiu, Feng, Whei, Jänne, Pasi A, Alvarez, James V, Zappaterra, Mauro, Bulmer, Sara E, Frank, David A, Hahn, William C, Sellers, William R, Meyerson, Matthew
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2005
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1240052/
https://ncbi.nlm.nih.gov/pubmed/16187797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0020313
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