Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity

Mutations in the EGFR kinase are a cause of non-small cell lung cancer. To understand their mechanism of activation and effects on drug binding, we studied the kinetics of the L858R and G719S mutants and determined their crystal structures with inhibitors including gefitinib, AEE788 and a staurospor...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Yun, Cai-Hong, Boggon, Titus J., Li, Yiqun, Woo, Michele S., Greulich, Heidi, Meyerson, Matthew, Eck, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939942/
https://ncbi.nlm.nih.gov/pubmed/17349580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.12.017
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Internet

https://ncbi.nlm.nih.gov/pmc/articles/PMC1939942/
https://ncbi.nlm.nih.gov/pubmed/17349580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.12.017