Á lódáil...
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity
Mutations in the EGFR kinase are a cause of non-small cell lung cancer. To understand their mechanism of activation and effects on drug binding, we studied the kinetics of the L858R and G719S mutants and determined their crystal structures with inhibitors including gefitinib, AEE788 and a staurospor...
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| Main Authors: | , , , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2007
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1939942/ https://ncbi.nlm.nih.gov/pubmed/17349580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.12.017 |
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