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The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small molecule tyrosine kinase inhibitors (TKIs), but the efficacy of these agents is often limited because of the emergence of drug resistance conferred by a second mutation, T790M...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2538882/ https://ncbi.nlm.nih.gov/pubmed/18227510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709662105 |
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