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Structural and Mechanistic Underpinnings of the Differential Drug Sensitivity of EGFR Mutations in Non-Small Cell Lung Cancer

EGFR and other ErbB-family tyrosine kinases are overexpressed in many human tumors, and their aberrant expression and mutational activation is associated with the development, progression and aggressiveness of a number of malignancies. Thus the EGFR kinase has long been recognized as a potential dru...

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Detalhes bibliográficos
Main Authors: Eck, Michael J., Yun, Cai-hong
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859716/
https://ncbi.nlm.nih.gov/pubmed/20026433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2009.12.010
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