The transforming potential of the c-erbB-2 protein is regulated by its autophosphorylation at the carboxyl-terminal domain.

The mutant c-erbB-2 protein with Glu instead of Val-659 exhibited transforming activity in NIH 3T3 cells. This protein showed enhanced tyrosine kinase activity in vitro and enhanced autophosphorylation at Tyr-1248 located proximal to the carboxyl terminus. Enhanced tyrosine phosphorylation of severa...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Akiyama, T, Matsuda, S, Namba, Y, Saito, T, Toyoshima, K, Yamamoto, T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359735/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1671296/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.2.833-842.1991
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