USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells

BACKGROUND: The deubiquitinase USP17 is overexpressed in NSCLC and has been shown to be required for the growth and motility of EGFR wild-type (WT) NSCLC cells. USP17 is also required for clathrin-mediated endocytosis of EGFR. Here, we examine the impact of USP17 depletion on the growth, as well as...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: McCann, Aidan P., Smyth, Peter, Cogo, Francesco, McDaid, William J., Jiang, Lai, Lin, Jia, Evergren, Emma, Burden, Roberta E., Van Schaeybroeck, Sandra, Scott, Christopher J., Burrows, James F.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6225634/
https://ncbi.nlm.nih.gov/pubmed/30409180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-018-0291-5
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