USP17 Regulates Ras Activation and Cell Proliferation by Blocking RCE1 Activity

The proto-oncogene Ras undergoes a series of post-translational modifications at its carboxyl-terminal CAAX motif that are essential for its proper membrane localization and function. One step in this process is the cleavage of the CAAX motif by the enzyme Ras-converting enzyme 1 (RCE1). Here we sho...

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Detalles Bibliográficos
Main Authors: Burrows, James F., Kelvin, Alyson A., McFarlane, Cheryl, Burden, Roberta E., McGrattan, Michael J., De la Vega, Michelle, Govender, Ureshnie, Quinn, Derek J., Dib, Karim, Gadina, Massimo, Scott, Christopher J., Johnston, James A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2666611/
https://ncbi.nlm.nih.gov/pubmed/19188362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807216200
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