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Mechanistic Insights into the Activation of Oncogenic Forms of EGF Receptor

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly activated by mutation in non-small cell lung cancer. The mechanism of this oncogenic activation is incompletely understood but, in contrast to the WT EGFR, is proposed to be independent of kinase domain dimerizati...

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Autori principali: Wang, Zhihong, Longo, Patti A., Tarrant, Mary Katherine, Kim, Kwangsoo, Head, Sarah, Leahy, Daniel J., Cole, Philip A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230693/
https://ncbi.nlm.nih.gov/pubmed/22101934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2168
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