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In Vitro Enzymatic Characterization of Near Full Length EGFR in Activated and Inhibited States

The epidermal growth factor receptor (EGFR) is a single-pass transmembrane protein with an extracellular ligand-binding region and a cytoplasmic tyrosine kinase. Ligand binding activates the tyrosine kinase, which in turn initiates signaling cascades that influence cell proliferation and differentia...

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Detalhes bibliográficos
Main Authors: Qiu, Chen, Tarrant, Mary K., Boronina, Tatiana, Longo, Patti A., Kavran, Jennifer M., Cole, Robert N., Cole, Philip A., Leahy, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747374/
https://ncbi.nlm.nih.gov/pubmed/19518076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900755n
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