Shear-Induced Unfolding and Enzymatic Cleavage of Full-Length VWF Multimers

Proteolysis of the multimeric blood coagulation protein von Willebrand Factor (VWF) by ADAMTS13 is crucial for prevention of microvascular thrombosis. ADAMTS13 cleaves VWF within the mechanosensitive A2 domain, which is believed to open under shear flow. In this study, we combine fluorescence correl...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Lippok, Svenja, Radtke, Matthias, Obser, Tobias, Kleemeier, Lars, Schneppenheim, Reinhard, Budde, Ulrich, Netz, Roland R., Rädler, Joachim O.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2016
Assuntos:
Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744175/
https://ncbi.nlm.nih.gov/pubmed/26840720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.12.023
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