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Shear-Induced Unfolding and Enzymatic Cleavage of Full-Length VWF Multimers
Proteolysis of the multimeric blood coagulation protein von Willebrand Factor (VWF) by ADAMTS13 is crucial for prevention of microvascular thrombosis. ADAMTS13 cleaves VWF within the mechanosensitive A2 domain, which is believed to open under shear flow. In this study, we combine fluorescence correl...
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| 出版年: | Biophys J |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Biophysical Society
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4744175/ https://ncbi.nlm.nih.gov/pubmed/26840720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.12.023 |
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