Mutation G1629E Increases von Willebrand Factor Cleavage via a Cooperative Destabilization Mechanism

The large multimeric glycoprotein von Willebrand Factor (VWF) plays a pivotal adhesive role during primary hemostasis. VWF is cleaved by the protease ADAMTS13 as a down-regulatory mechanism to prevent excessive VWF-mediated platelet aggregation. For each VWF monomer, the ADAMTS13 cleavage site is lo...

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Detalles Bibliográficos
Publicado en:Biophys J
Autores principales: Aponte-Santamaría, Camilo, Lippok, Svenja, Mittag, Judith J., Obser, Tobias, Schneppenheim, Reinhard, Baldauf, Carsten, Gräter, Frauke, Budde, Ulrich, Rädler, Joachim O.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2017
Materias:
Proteins
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5232862/
https://ncbi.nlm.nih.gov/pubmed/28076816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.11.3202
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