Force-Sensitive Autoinhibition of the von Willebrand Factor Is Mediated by Interdomain Interactions

Von Willebrand factor (VWF) plays a central role in hemostasis. Triggered by shear-stress, it adheres to platelets at sites of vascular injury. Inactivation of VWF has been associated to the shielding of its adhesion sites and proteolytic cleavage. However, the molecular nature of this shielding and...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Aponte-Santamaría, Camilo, Huck, Volker, Posch, Sandra, Bronowska, Agnieszka K., Grässle, Sandra, Brehm, Maria A., Obser, Tobias, Schneppenheim, Reinhard, Hinterdorfer, Peter, Schneider, Stefan W., Baldauf, Carsten, Gräter, Frauke
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2015
Assuntos:
Proteins and Nucleic Acids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423058/
https://ncbi.nlm.nih.gov/pubmed/25954888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.03.041
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados