Force-Sensitive Autoinhibition of the von Willebrand Factor Is Mediated by Interdomain Interactions

Von Willebrand factor (VWF) plays a central role in hemostasis. Triggered by shear-stress, it adheres to platelets at sites of vascular injury. Inactivation of VWF has been associated to the shielding of its adhesion sites and proteolytic cleavage. However, the molecular nature of this shielding and...

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Bibliografski detalji
Izdano u:Biophys J
Glavni autori: Aponte-Santamaría, Camilo, Huck, Volker, Posch, Sandra, Bronowska, Agnieszka K., Grässle, Sandra, Brehm, Maria A., Obser, Tobias, Schneppenheim, Reinhard, Hinterdorfer, Peter, Schneider, Stefan W., Baldauf, Carsten, Gräter, Frauke
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2015
Teme:
Proteins and Nucleic Acids
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423058/
https://ncbi.nlm.nih.gov/pubmed/25954888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.03.041
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