Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor

Von Willebrand factor (VWF) is a key player in the regulation of hemostasis by promoting recruitment of platelets to sites of vascular injury. An array of 6 C domains forms the dimeric C-terminal VWF stem. Upon shear force activation, the stem adopts an open conformation allowing the adhesion of VWF...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Xu, Emma-Ruoqi, von Bülow, Sören, Chen, Po-Chia, Lenting, Peter J., Kolšek, Katra, Aponte-Santamaría, Camilo, Simon, Bernd, Foot, Jaelle, Obser, Tobias, Schneppenheim, Reinhard, Gräter, Frauke, Denis, Cécile V., Wilmanns, Matthias, Hennig, Janosch
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2019
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450055/
https://ncbi.nlm.nih.gov/pubmed/30305279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-04-843615
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