Chargement en cours...
Shear-Induced Unfolding and Enzymatic Cleavage of Full-Length VWF Multimers
Proteolysis of the multimeric blood coagulation protein von Willebrand Factor (VWF) by ADAMTS13 is crucial for prevention of microvascular thrombosis. ADAMTS13 cleaves VWF within the mechanosensitive A2 domain, which is believed to open under shear flow. In this study, we combine fluorescence correl...
Enregistré dans:
| Publié dans: | Biophys J |
|---|---|
| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Biophysical Society
2016
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4744175/ https://ncbi.nlm.nih.gov/pubmed/26840720 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.12.023 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|