Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death

The present studies were initiated to determine in greater molecular detail the regulation of CHK1 inhibitor lethality in transfected and infected breast cancer cells and using genetic models of transformed fibrobalsts. Multiple MEK1/2 inhibitors (PD184352, AZD6244 [ARRY-142886]) interacted with mul...

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Bibliografiske detaljer
Main Authors: Mitchell, Clint, Hamed, Hossein A, Cruickshanks, Nichola, Tang, Yong, Bareford, M. Danielle, Hubbard, Nisan, Tye, Gary, Yacoub, Adly, Dai, Yun, Grant, Steven, Dent, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2011
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230482/
https://ncbi.nlm.nih.gov/pubmed/21642769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.3.16218
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