Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death

The present studies were initiated to determine in greater molecular detail the regulation of CHK1 inhibitor lethality in transfected and infected breast cancer cells and using genetic models of transformed fibrobalsts. Multiple MEK1/2 inhibitors (PD184352, AZD6244 [ARRY-142886]) interacted with mul...

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Autori principali: Mitchell, Clint, Hamed, Hossein A, Cruickshanks, Nichola, Tang, Yong, Bareford, M. Danielle, Hubbard, Nisan, Tye, Gary, Yacoub, Adly, Dai, Yun, Grant, Steven, Dent, Paul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230482/
https://ncbi.nlm.nih.gov/pubmed/21642769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.3.16218
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