Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death

The present studies were initiated to determine in greater molecular detail the regulation of CHK1 inhibitor lethality in transfected and infected breast cancer cells and using genetic models of transformed fibrobalsts. Multiple MEK1/2 inhibitors (PD184352, AZD6244 [ARRY-142886]) interacted with mul...

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Autors principals: Mitchell, Clint, Hamed, Hossein A, Cruickshanks, Nichola, Tang, Yong, Bareford, M. Danielle, Hubbard, Nisan, Tye, Gary, Yacoub, Adly, Dai, Yun, Grant, Steven, Dent, Paul
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2011
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230482/
https://ncbi.nlm.nih.gov/pubmed/21642769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.3.16218
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