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CHK1 Inhibitors in Combination Chemotherapy: Thinking Beyond the Cell Cycle

Cellular sensing of DNA damage, along with concomitant cell cycle arrest, is mediated by a great many proteins and enzymes. One focus of pharmaceutical development has been the inhibition of DNA damage signaling, and checkpoint kinases (Chks) in particular, as a means to sensitize proliferating tumo...

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Detalhes bibliográficos
Main Authors: Dent, Paul, Tang, Yong, Yacoub, Adly, Dai, Yun, Fisher, Paul B., Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109860/
https://ncbi.nlm.nih.gov/pubmed/21540473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mi.11.2.11
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