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CHK1 Inhibitors in Combination Chemotherapy: Thinking Beyond the Cell Cycle
Cellular sensing of DNA damage, along with concomitant cell cycle arrest, is mediated by a great many proteins and enzymes. One focus of pharmaceutical development has been the inhibition of DNA damage signaling, and checkpoint kinases (Chks) in particular, as a means to sensitize proliferating tumo...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Pharmacology and Experimental Therapeutics
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3109860/ https://ncbi.nlm.nih.gov/pubmed/21540473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mi.11.2.11 |
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