IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors

Solid tumors are complex masses with a local microenvironment, or stroma, that supports tumor growth and progression. Among the diverse tumor-supporting stromal cells is a heterogeneous population of myeloid-derived cells. These cells are alternatively activated and contribute to the immunosuppressi...

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Autores principales: Kerkar, Sid P., Goldszmid, Romina S., Muranski, Pawel, Chinnasamy, Dhanalakshmi, Yu, Zhiya, Reger, Robert N., Leonardi, Anthony J., Morgan, Richard A., Wang, Ena, Marincola, Francesco M., Trinchieri, Giorgio, Rosenberg, Steven A., Restifo, Nicholas P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226001/
https://ncbi.nlm.nih.gov/pubmed/22056381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI58814
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