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Antibacterial and Antitubercular Activity of Fosmidomycin, FR900098, and their Lipophilic Analogs

The nonmevalonate pathway (NMP) of isoprene biosynthesis is an exciting new route toward novel antibiotic development. Inhibitors against several enzymes in this pathway are currently under examination. A significant liability of many of these agents is poor cell penetration. To overcome and improve...

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Autors principals: Uh, Eugene, Jackson, Emily R., Jose, Géraldine San, Maddox, Marcus, Lee, Robin E., Lee, Richard E., Boshoff, Helena I., Dowd, Cynthia S.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215086/
https://ncbi.nlm.nih.gov/pubmed/22024034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.09.123
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