The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs

Inhibition of the nonmevalonate pathway (NMP) of isoprene biosynthesis has been examined as a source of new antibiotics with novel mechanisms of action. Dxr is the best studied of the NMP enzymes and several reports have described potent Dxr inhibitors. Many of these compounds are structurally relat...

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Main Authors: Jackson, Emily R., Jose, Géraldine San, Brothers, Robert C., Edelstein, Emma K., Sheldon, Zachary, Haymond, Amanda, Johny, Chinchu, Boshoff, Helena I., Couch, Robin D., Dowd, Cynthia S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3927493/
https://ncbi.nlm.nih.gov/pubmed/24360562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.11.067
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