Design of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)—Evidence of a Novel Binding Mode

In most bacteria, the nonmevalonate pathway is used to synthesize isoprene units. Dxr, the second step in the pathway, catalyzes the NADPH-dependent reductive isomerization of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol-4-phosphate (MEP). Dxr is inhibited by natural products fosm...

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Detalhes bibliográficos
Main Authors: San Jose, Géraldine, Jackson, Emily R., Uh, Eugene, Johny, Chinchu, Haymond, Amanda, Lundberg, Lindsay, Pinkham, Chelsea, Kehn-Hall, Kylene, Boshoff, Helena I., Couch, Robin D., Dowd, Cynthia S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731163/
https://ncbi.nlm.nih.gov/pubmed/23914289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD00085K
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