Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase)

The methylerythritol phosphate (MEP) pathway found in many bacteria governs the synthesis of isoprenoids, which are crucial lipid precursors for vital cell components such as ubiquinone. Because mammals synthesize isoprenoids via an alternate pathway, the bacterial MEP pathway is an attractive targe...

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Détails bibliographiques
Auteurs principaux: Haymond, Amanda, Johny, Chinchu, Dowdy, Tyrone, Schweibenz, Brandon, Villarroel, Karen, Young, Richard, Mantooth, Clark J., Patel, Trishal, Bases, Jessica, Jose, Geraldine San, Jackson, Emily R., Dowd, Cynthia S., Couch, Robin D.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149570/
https://ncbi.nlm.nih.gov/pubmed/25171339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106243
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