Lipophilic Prodrugs of FR900098 Are Antimicrobial against Francisella novicida In Vivo and In Vitro and Show GlpT Independent Efficacy

Bacteria, plants, and algae produce isoprenoids through the methylerythritol phosphate (MEP) pathway, an attractive pathway for antimicrobial drug development as it is present in prokaryotes and some lower eukaryotes but absent from human cells. The first committed step of the MEP pathway is catalyz...

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Detalhes bibliográficos
Main Authors: McKenney, Elizabeth S., Sargent, Michelle, Khan, Hameed, Uh, Eugene, Jackson, Emily R., Jose, Géraldine San, Couch, Robin D., Dowd, Cynthia S., van Hoek, Monique L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471904/
https://ncbi.nlm.nih.gov/pubmed/23077474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038167
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