Lipophilic Prodrugs of FR900098 Are Antimicrobial against Francisella novicida In Vivo and In Vitro and Show GlpT Independent Efficacy

Bacteria, plants, and algae produce isoprenoids through the methylerythritol phosphate (MEP) pathway, an attractive pathway for antimicrobial drug development as it is present in prokaryotes and some lower eukaryotes but absent from human cells. The first committed step of the MEP pathway is catalyz...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: McKenney, Elizabeth S., Sargent, Michelle, Khan, Hameed, Uh, Eugene, Jackson, Emily R., Jose, Géraldine San, Couch, Robin D., Dowd, Cynthia S., van Hoek, Monique L.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471904/
https://ncbi.nlm.nih.gov/pubmed/23077474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038167
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы